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Enhanced penetration strategies for transdermal delivery

Qiaofei Pan, Yinglin Yu, Dong Chen, Genlong Jiao, Xiaowen Liu

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 3,   Pages 378-388 doi: 10.1007/s11705-019-1913-1

Abstract: Transdermal delivery offers several advantages in drug distribution, including convenience, painless administration, avoidance of first-pass metabolism, and ease of termination. However, the natural protective barriers of the skin, such as the stratum corneum, the topmost layer of skin, limit the systemic absorption of external therapeutics via transdermal delivery. Therefore, extensive application of transdermal delivery in medical treatment has been limited. Over the past few years, many formulation strategies and physical technologies, therefore, have been developed to enhance transdermal delivery. This review summarizes various formulation strategies proposed for transdermal delivery and their application in medical treatment.

Keywords： transdermal delivery     stratum corneum     enhanced penetration     therapeutics    

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Hollow-fiber gas penetration electrodes efficiently produce renewable synthetic fuels

Frontiers in Energy 2022, Volume 16, Issue 5,   Pages 700-705 doi: 10.1007/s11708-022-0842-8

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Liquefaction prediction using support vector machine model based on cone penetration data

Pijush SAMUI

Frontiers of Structural and Civil Engineering 2013, Volume 7, Issue 1,   Pages 72-82 doi: 10.1007/s11709-013-0185-y

Abstract: This paper examines the potential of SVM model in prediction of liquefaction using actual field cone penetration

Keywords： earthquake     cone penetration test     liquefaction     support vector machine (SVM)     prediction    

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In situ-based assessment of soil liquefaction potential–Case study of an earth dam in Tunisia

Ikram GUETTAYA,Mohamed Ridha EL OUNI

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 4,   Pages 456-461 doi: 10.1007/s11709-014-0259-5

Abstract: The present paper examines the evaluation of liquefaction potential of an earth dam foundation in Tunisia. The assessment of soil liquefaction was made using deterministic and probabilistic simplified procedures developed from several case histories. The data collected from the field investigation performed before and after the vibrocompaction are analyzed and the results are reported. The obtained results show that after vibrocompaction, a significant improvement of the soil resistance reduces the liquefaction potential of the sandy foundation. Indeed, in the untreated layers, the factor of safety drops below 1 which means that the soil is susceptible for liquefaction. However, in the compacted horizons, the values of exceed the unit which justifies the absence of liquefaction hazard of the foundation.

Keywords： liquefaction     cone penetration test (CPT)     standard penetration test (SPT)     vibrcompaction     sand    

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Influence of short chain ceramides and lipophilic penetration enhancers on the nano-structure of stratum

Annett SCHROETER, Tanja ENGELBRECHT, Reinhard H. H. NEUBERT

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 29-36 doi: 10.1007/s11705-013-1302-0

Abstract: the influence of the short chain ceramides (CER)[NP] and [AP] as well as the impact of the lipophilic penetrationThe penetration enhancer OA has not influenced the repeat distance of the model membrane based on CERIPM showed the same effect but two phases (assigned as phase A and B) appeared, when IPM was used as penetration

Keywords： nano-structure of the stratum corneum     ceramide     penetration enhancer     model membrane     neutron diffraction    

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Study of mechanism of activating flux increasing weld penetration of AC A-TIG welding for aluminum alloy

HUANG Yong, FAN Ding, FAN Qinghua

Frontiers of Mechanical Engineering 2007, Volume 2, Issue 4,   Pages 442-447 doi: 10.1007/s11465-007-0076-9

Abstract: DCEN) and direct current electrode positive (DCEP), respectively, the flux differently affects weld penetrationAfter studied the effect of compelled arc con striction on weld penetration of AC welding, it is believedThe penetration has a relationship with the separate distribution of slag on the weld surface.The relationship between slag distribution and weld penetration was studied by adding aluminum powderFinally, the weld penetration is increased.

Keywords： A-TIG welding     surface     DCEN     electrode negative     increase    

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NIG-AP: a newmethod for automated penetration testing Regular Papers-Research Articles

Tian-yang ZHOU, Yi-chao ZANG, Jun-hu ZHU, Qing-xian WANG

Frontiers of Information Technology & Electronic Engineering 2019, Volume 20, Issue 9,   Pages 1277-1298 doi: 10.1631/FITEE.1800532

Abstract: Penetration testing offers strong advantages in the discovery of hidden vulnerabilities in a networkThe natural way to deal with the above problem is automated penetration testing, the essential part ofpaths, all of them require perfect network information beforehand, which is contradictory to realistic penetrationThe algorithm formalizes penetration testing as a Markov decision process and uses network information

Keywords： Penetration testing     Reinforcement learning     Classical planning     Partially observable Markov decision process    

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Penetration Depth of Projectiles Into Concrete Using Artificial Neural Network

Li Jianguang,Li Yongchi,Wang Yulan

Strategic Study of CAE 2007, Volume 9, Issue 8,   Pages 77-81

Abstract: . , and output of penetration depth is established by dimensional analysis and theory of artificial neuralnetworks for problem of penetration depth of projectiles into concrete. Moreover,  a satisfied output about penetration depth from RBF neural network is gotten by

Keywords： neural networks     dimensional analysis     penetration depth of projectiles into concrete     nonlinear mapping    

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between concrete-filled steel tubular column and steel beam with narrow outer diaphragm and partial joint penetration

Chunyan QUAN,Wei WANG,Jian ZHOU,Rong WANG

Frontiers of Structural and Civil Engineering 2016, Volume 10, Issue 3,   Pages 333-344 doi: 10.1007/s11709-016-0357-7

Abstract: between concrete-filled steel tubular column and steel beam with narrow outer diaphragm and partial joint penetrationthe narrow outer diaphragm connected to the concrete-filled steel tubular column with partial joint penetration

Keywords： narrow outer diaphragm     concrete-filled tubular column     joint     inner and outer stiffening     cyclic behavior    

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Prediction of the shear wave velocity

Amoroso SARA

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 1,   Pages 83-92 doi: 10.1007/s11709-013-0234-6

Abstract: obtain rough estimates of the shear wave velocity from non-seismic dilatometer tests (DMT) and cone penetration

Keywords： horizontal stress index     shear wave velocity     flat dilatometer test     cone penetration test    

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Nanoparticle-enhanced coolants in machining: mechanism, application, and prospects

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 4, doi: 10.1007/s11465-023-0769-8

Abstract: Nanoparticle-enhanced coolants (NPECs) are increasingly used in minimum quantity lubrication (MQL) machiningFirst, the laws of influence of nano-enhanced phases and base fluids on the processing performance areand physical properties of NPECs are combined to elucidate their unique mechanisms of heat transfer, penetration

Keywords： nanoparticle-enhanced coolant     minimum quantity lubrication     biolubricant     thermophysical properties    

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A review on the application of nanofluids in enhanced oil recovery

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 8,   Pages 1165-1197 doi: 10.1007/s11705-021-2120-4

Abstract: Enhanced oil recovery (EOR) has been widely used to recover residual oil after the primary or secondary

Keywords： nanofluid     EOR mechanism     nanoparticle adsorption     interface property     internal property    

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Generation of enhanced stability of SnO/In(OH)/InP for photocatalytic water splitting by SnO protection

Frontiers in Energy 2021, Volume 15, Issue 3,   Pages 710-720 doi: 10.1007/s11708-021-0764-x

Abstract: paper, it is demonstrated that the stability and activity of the InP-based catalyst are effectively enhanced

Keywords： SnO/In(OH)3/InP photocatalyst     enhanced activity and stability for water splitting     corrosion    

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CO, N, and CO/N mixed gas injection for enhanced shale gas recovery and CO geological storage

Frontiers in Energy 2023, Volume 17, Issue 3,   Pages 428-445 doi: 10.1007/s11708-023-0865-9

Abstract: In this work, using fractured shale cores, isothermal adsorption experiments and core flooding tests were conducted to investigate the performance of injecting different gases to enhance shale gas recovery and CO2 geological storage efficiency under real reservoir conditions. The adsorption process of shale to different gases was in agreement with the extended-Langmuir model, and the adsorption capacity of CO2 was the largest, followed by CH4, and that of N2 was the smallest of the three pure gases. In addition, when the CO2 concentration in the mixed gas exceeded 50%, the adsorption capacity of the mixed gas was greater than that of CH4, and had a strong competitive adsorption effect. For the core flooding tests, pure gas injection showed that the breakthrough time of CO2 was longer than that of N2, and the CH4 recovery factor at the breakthrough time (RCH4) was also higher than that of N2. The RCH4 of CO2 gas injection was approximately 44.09%, while the RCH4 of N2 was only 31.63%. For CO2/N2 mixed gas injection, with the increase of CO2 concentration, the RCH4 increased, and the RCH4 for mixed gas CO2/N2 = 8:2 was close to that of pure CO2, about 40.24%. Moreover, the breakthrough time of N2 in mixed gas was not much different from that when pure N2 was injected, while the breakthrough time of CO2 was prolonged, which indicated that with the increase of N2 concentration in the mixed gas, the breakthrough time of CO2 could be extended. Furthermore, an abnormal surge of N2 concentration in the produced gas was observed after N2 breakthrough. In regards to CO2 storage efficiency (Sstorage-CO2), as the CO2 concentration increased, Sstorage-CO2 also increased. The Sstorage-CO2 of the pure CO2 gas injection was about 35.96%, while for mixed gas CO2/N2 = 8:2, Sstorage-CO2 was about 32.28%.

Keywords： shale gas     gas injection     competitive adsorption     enhanced shale gas recovery     CO2 geological    

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A MYB-INDUCED MECHANISM FOR ENHANCED ASCORBATE IN RED-FLESHED APPLES

Richard V. ESPLEY, Kuilin WANG

Frontiers of Agricultural Science and Engineering   Pages 356-357 doi: 10.15302/J-FASE-2021381

Abstract: These red-fleshed apples have enhanced concentrations of both anthocyanins and ascorbate, both of which
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Title Author Date Type Operation

Enhanced penetration strategies for transdermal delivery

Qiaofei Pan, Yinglin Yu, Dong Chen, Genlong Jiao, Xiaowen Liu

Journal Article

Hollow-fiber gas penetration electrodes efficiently produce renewable synthetic fuels

Journal Article

Liquefaction prediction using support vector machine model based on cone penetration data

Pijush SAMUI

Journal Article

In situ-based assessment of soil liquefaction potential–Case study of an earth dam in Tunisia

Ikram GUETTAYA,Mohamed Ridha EL OUNI

Journal Article

Influence of short chain ceramides and lipophilic penetration enhancers on the nano-structure of stratum

Annett SCHROETER, Tanja ENGELBRECHT, Reinhard H. H. NEUBERT

Journal Article

Study of mechanism of activating flux increasing weld penetration of AC A-TIG welding for aluminum alloy

HUANG Yong, FAN Ding, FAN Qinghua

Journal Article

NIG-AP: a newmethod for automated penetration testing

Tian-yang ZHOU, Yi-chao ZANG, Jun-hu ZHU, Qing-xian WANG

Journal Article

Penetration Depth of Projectiles Into Concrete Using Artificial Neural Network

Li Jianguang,Li Yongchi,Wang Yulan

Journal Article

between concrete-filled steel tubular column and steel beam with narrow outer diaphragm and partial joint penetration

Chunyan QUAN,Wei WANG,Jian ZHOU,Rong WANG

Journal Article

Prediction of the shear wave velocity

Amoroso SARA

Journal Article

Nanoparticle-enhanced coolants in machining: mechanism, application, and prospects

Journal Article

A review on the application of nanofluids in enhanced oil recovery

Journal Article

Generation of enhanced stability of SnO/In(OH)/InP for photocatalytic water splitting by SnO protection

Journal Article

CO, N, and CO/N mixed gas injection for enhanced shale gas recovery and CO geological storage

Journal Article

A MYB-INDUCED MECHANISM FOR ENHANCED ASCORBATE IN RED-FLESHED APPLES

Richard V. ESPLEY, Kuilin WANG

Journal Article